The Blue Devils improved to 16-0 overall and 5-0 on the year, continuing their second-best start in school history.
Duke improves to 4-1 in the series with Boston College.
The Blue Devils finished with a season-low 66 points.
Duke played its third game of a four-game road trip and played its seventh game over the last 17 days.
For the second straight game, Duke had season-lows in first half points (20) and first half field goal percentage (25.9).
The Blue Devils didn't score their first basket until the 16:16 mark of the first half, which was the longest scoreless streak to open a game this season for Duke. Boston College was held scoreless until the 13:17 mark.
Duke trailed at the end of the first half for the first time this season.
Duke blocked six shots in the first half and finished the contest with seven.
With her 20 points, senior Monique Currie moved into third place on the Duke all-time scoring list. She now owns 1,793 career points. She also moved into 25th place on the ACC all-time scoring list. Currie also grabbed seven rebounds, had four assists and hit 7-of-12 field goals.
Monique Currie posted her fourth game with 20 or more points.
In the second half, the Blue Devils faced the largest deficit on the season (9).
For the fifth straight ACC game, Lindsey Harding scored double-figure points as she finished with 18. She also dished out five assists and had four steals in 31 minutes.
Duke shot 64.3 from the field in the second half and closed the game on a 17-2 run.
Duke will next travel to Holy Cross on Monday, Jan. 16 for a 7:00 p.m. tip, before returning home to face N.C. State on Thursday, Jan. 19 at 7 p.m.