The Blue Devils allowed a season-high 54 points on the afternoon.
Duke won its 35th out of the last 37 road ACC games.
The Blue Devils won its 63rd straight game against an unranked opponent.
Duke improved to 8-2 in the series versus Virginia Tech and won its sixth in a row.
Duke forced one shot clock violation on the day and now has forced 15 in 16 games played.
The Blue Devils had two players?Abby Waner (20) and Lindsey Harding (20)?score 20 on the day marking the first time this season two players have scored 20 points in the same game for Duke.
The 27 points scored in the first half by Virginia Tech matches the most scored against the Blue Devils this season in the first stanza (Texas & Pittsburgh).
Junior Emily Waner extended her consecutive games with at least one three-pointer to 11 straight on Sunday as she hit 1-of-3 from downtown.
With her five blocks on the afternoon, senior Alison Bales moved into tied for 14th place on the NCAA all-time blocked shot list with a total of 357.
Senior Lindsey Harding notched 20 points on the afternoon marking her eighth time over the last 10 contests she has notched double-digit scoring. It was the second time this season she has scored 20 or more points.
After scoring 14 points over the last two games, junior Wanisha Smith scored 14 points in the first half on Sunday, a total she also finished the game with.
Duke held an 18-0 advantage on fast break points in the first half and went on to finish the game leading, 32-4.
With her five assists on the day, senior Lindsey Harding moved into 16th place on the ACC career assist list with 512. She also moved past former Duke All-America Alana Beard (509) into second place on the Blue Devil all-time assist chart.
The Blue Devils continued their hot free throw shooting nailing 19-of-22 for the game. Abby Waner posted double-digit scoring for the 14th time out of 16 games with her 20 points. She also had two rebounds, four assists and three steals.
After hitting only 4-of-28 three-pointers the last two contests, Duke came out and hit 4-of-10 treys in the first half to jump out to a 14 point lead over the Hokies. The Blue Devils finished the game hitting 5-of-14.
Duke will next return home as the Blue Devils host Georgia Tech on Wednesday, Jan. 10 at 7 p.m., in Cameron Indoor Stadium.